|
KMID : 0381920100400030133
|
|
Korean Journal of Microscopy
2010 Volume.40 No. 3 p.133 ~ p.138
|
|
|
Cisplatin and Extract of Tissue Cultured Mountain Ginseng-Induced Apoptosis in Human Cervical Cancer Cells
|
|
Lee Myeong-Seon
|
|
|
Abstract
|
|
|
|
Mountain ginseng is a perennial crop rarely found in the deep mountains of Korea. The medicinal effect of the mountain ginseng is well known as a panacea in traditional Chinese medicine for a long time. But scientific studies to elucidate the medicinal effect of the mountain ginseng have never been made on account of lack of sample. Recently an improved method of adventitious root culture system through the use of bioreactor has been developed in Panax ginseng that seems to be a reliable way of commercialization of root derived secondary metabolites. This experiment was conducted to evaluated chemotherapeutic effect against human cervical cancer cells by cisplatin (CDDP) and extract of tissue cultured mountain ginseng (ETCMG). CDDP and ETCMG-induced apoptotic cell death in human cervical cancer cell line, HeLa was confirmed by the analysis of cell growth, morphological changes, DNA fragmentation, flow cytometry showed that ETCMG is an inducer of apoptosis and synergizes with CDDP. These results suggest that ETCMG present evidence of anticancer effect and could have a possibly natural therapeutic potential in cervical cancer patients.
|
|
|
KEYWORD
|
|
|
Cervical cancer, Cisplatin, Extract of tissue cultured mountain ginseng
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|